NADH dehydrogenase - Übersetzung nach arabisch
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NADH dehydrogenase - Übersetzung nach arabisch

ENZYME OF THE RESPIRATORY CHAIN CONSISTING OF SEVERAL POLYPEPTIDE CHAINS AND L-SHAPED, WITH A HORIZONTAL ARM LYING IN THE MEMBRANE AND A VERTICAL ARM THAT PROJECTS INTO THE MATRIX.
Complex I; Nadh dehydrogenase; Complex 1; Mitochondrial complex I; EC 1.6.5.3; NADH:ubiquinone reductase (H+-translocating); NADH dehydrogenase (ubiquinone); NADH:ubiquinone reductase; NADH:ubiquinone oxidoreductase (H+-translocating)
  • NADH Dehydrogenase Mechanism: 
1. The seven primary iron sulfur centers serve to carry electrons from the site of NADH dehydration to ubiquinone. Note that N7 is not found in eukaryotes.

2. There is a reduction of ubiquinone (CoQ) to ubiquinol (CoQH<sub>2</sub>).

3. The energy from the redox reaction results in conformational change allowing hydrogen ions to pass through four transmembrane helix channels.

NADH dehydrogenase         
CLASS OF ENZYMES
Complex1; NADH-Q reductase; EC 1.6.99.3; NADH:acceptor oxidoreductase
‎ نازِعَةُ هيدروجِينِ ثُنائِيِّ نوكليوتيد النِّيكوتينِ و الأَدنين‎
alcohol dehydrogenase         
CLASS OF ENZYMES
Cytosolic ADH; Liver alcohol dehydrogenase; Racker unit; Alcohol dehydrogenases; EC 1.1.1.1; Alcohol:NAD+ oxidoreductase
‎ نازِعَةُ هِيدروجينِ الكُحُولِ‎
lactic dehydrogenase         
  • 400px
  • Arrow pushing mechanism for the reaction catalyzed by lactate dehydrogenase
  • Reaction catalyzed by lactate dehydrogenase
CLASS OF ENZYMES
Lactic acid dehydrogenase; L-lactate dehydrogenase; Lactate dehydrogenases; Lactic dehydrogenase; EC 1.1.1.27; (S)-lactate:NAD+ oxidoreductase; Glycogen storage disease type XI
‎ نازِعَةُ هيدروجينِ اللَّاكْتات‎

Definition

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Wikipedia

Respiratory complex I

Respiratory complex I, EC 7.1.1.2 (also known as NADH:ubiquinone oxidoreductase, Type I NADH dehydrogenase and mitochondrial complex I) is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.

This enzyme is essential for the normal functioning of cells, and mutations in its subunits lead to a wide range of inherited neuromuscular and metabolic disorders. Defects in this enzyme are responsible for the development of several pathological processes such as ischemia/reperfusion damage (stroke and cardiac infarction), Parkinson's disease and others.